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Array Celebrates BEACON Of Hope For Anti-BRAF/MEK/EGFR Triplet In Colorectal Cancer

 
• By Eleanor Malone

New data on Array BioPharma's encorafenib and binimetinib together with cetuximab add hopes for its future in colorectal cancer. Recent strong data in melanoma for the BRAF/MEK combo are expected to be followed by its first US approval in the coming days.

a beautiful beacon appears on a foggy day
Beacon of hope for Array in CRC

Overall survival data from Array BioPharma Inc.'s Phase III BEACON CRC safety lead-in trial of its BRAF inhibitor encorafenib, MEK inhibitor binimetinib, and Eli Lilly & Co./Merck KGaA's anti-EGFR antibody Erbitux (cetuximab) suggest the triplet combination could prove valuable as a treatment for BRAF V600E-mutant metastatic colorectal cancer (mCRC).

Array reported at the European Society of Medical Oncology's gastrointestinal cancer conference (ESMO-GI) in Barcelona June 23 that the combo...

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J&J’s Trispecific Antibody For Myeloma Offers Improved Safety, Potency Over Bispecifics

 
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ASCO: Pushing The Frontiers Of ADCs

 
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Antibody-drug conjugates are a major part of the oncology pipeline, and data presented at the American Society of Clinical Oncology meeting highlight the emergence of new technologies.

Immuneering Could Partner Atebimetinib Or Go It Alone After Phase IIa Success

 
• By Alaric DeArment

CEO Ben Zeskind said all options are on the table after atebimetinib showed impressive results in pancreatic cancer.

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• By Kevin Grogan

The off-the-shelf stem cell therapy shows sustained glycemic control and a high rate of insulin independence.

Obesity Treatment Could Go Global With Lilly’s Orforglipron

 
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Shigella Vaccine Pipeline And Why It Matters

 
• By Vibha Ravi

A GSK-Bharat Biotech deal on a shigella vaccine candidate has cast a spotlight on the disease, which is the second leading cause of diarrheal deaths in children below five. Scrip looks at data from Pharmaprojects, WHO and other sources to highlight why a vaccine matters and what pharma is doing.