Step one after its acquisition of TxCell SA will be for Sangamo Therapeutics Inc. to advance the former's lead preclinical chimeric-antigen receptor-modified regulatory T-cell – or CAR-Treg – candidate into the clinic. The first program Sangamo expects to take into Phase I/II studies is TX200, an autologous, lentivirus-based candidate to induce immunologic tolerance in solid organ transplant; it anticipates applying for the clinical trial authorization in renal transplant Europe in 2019 and starting the trial later in the year.
Sangamo Buys TxCell To Get In Early on CAR-Tregs In Immunology
Sangamo is to pay €72m to acquire France's TxCell, a specialist in chimeric antigen receptor-modified regulatory T-cells. It hopes ultimately to apply its zinc finger nuclease gene editing technology to develop next-generation allogeneic CAR-Treg therapies for immunological conditions.
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