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Poxel Adds To NASH Pipeline With Novel Single-Isomer Pioglitazone

 
• By John Davis

Some ground-breaking chemistry has been used to produce a single isomer of pioglitazone, which has been acquired by France's Poxel to evaluate in NASH, adding to its portfolio of potential metabolic disease therapies.  

Liver
• Source: Shutterstock

France's metabolic diseases company Poxel SA has licensed a difficult-to-make single-isomer candidate drug, DRX-065, from US firm DeuteRx LLC, which has potential in the treatment of non-alcoholic steatohepatitis (NASH), and may be developed quickly because the racemic parent, pioglitazone, is already on the market, for type 2 diabetes.

The deal is the latest move by Poxel to concentrate its mid-stage research efforts on NASH – it has another...

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