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"Impressive" HbA1c And Weight Reductions Spur Phase III Plans For Lilly's Dual Incretin Agonist

 
• By John Davis

Heading into Phase III in 2019 is Lilly's dual agonist of GLP-1 and GIP, which has shown notable therapeutic effects on blood sugar and body weight in type 2 diabetics in a mid-stage clinical study. Meanwhile Lilly/Boehringer Ingelheim's SGLT2 inhibitor, empagliflozin, is being discussed with regulators with regard to its use in type 1 diabetics, an additional indication, following the release of full results from the EASE Phase III program.

Scales

Eli Lilly & Co. is moving ahead quickly with LY3298176, a dual agonist of two incretins which has shown strong beneficial effects on HbA1c and body weight in a Phase IIb study in type 2 diabetics, and expects to start Phase III studies in type 2 diabetes "no later than early 2019". If successful, the investigational compound could be a significant competitor to GLP-1 agonists such as Novo Nordisk AS's semaglutide in the condition.

Lilly is also evaluating next steps for the evaluation of dual GIP/GLP-1 receptor agonists like LY-3298176 in the treatment of obesity and for other conditions, the company announced on Oct

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