CLL Sector Heats Up, AbbVie/Roche Upbeat About First-Line Venetoclax Combo

Positive top-line data on use of an AbbVie/Genentech's venetoclax combination as a first-line chronic lymphocytic leukemia therapy heralds stiffer competition in the therapeutic sector in the years to come.  

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CLL market is likely to see increased competition • Source: Shutterstock.

AbbVie Inc. and Roche have announced their first-in-class BCL-2 inhibitor, venetoclax (Venclexta in the US, Venclyxto in Europe) has met the primary endpoint in a German clinical study which could allow the drug's indications to be extended to the first-line treatment of chronic lymphocytic leukemia (CLL), a therapeutic sector shaping up to become notably competitive.

The use of a combination of venetoclax and Roche/Biogen Inc.'s anti-CD20 MAb, Gazyva (obinutuzumab) for a fixed duration of...

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