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Madrigal Cements Case For Hepatic Fat Reduction, Other NASH Benefits With MGL-3196

 
• By Joseph Haas

Madrigal’s selective THR beta agonist continues to demonstrate hepatic fat-lowering abilities in 36-week data, along with lipid-lowering characteristics. The company hopes to initiate a Phase III study in early 2019.

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Madrigal Pharmaceuticals Inc.’s updated 36-week biopsy data for its THR beta agonist MGL-3196 in non-alcoholic steatohepatitis (NASH) shows a statistically significant ability to reduce hepatic fat across multiple measures, likely positioning the compound to enter Phase III development in early 2019.

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