ASH Preview: BCMA-Targeting CAR-Ts And Bispecifics Hog The Spotlight

Some of the most anticipated data at ASH are for therapies targeting BCMA in multiple myeloma, including a next-gen CAR-T from bluebird and Celgene as well as Amgen's novel BiTE, but an update from China's Legend Biotech and J&J could steal the show.

Multiple Myeloma Awareness: Bone marrow aspirate cytology of multiple myeloma, a type of bone marrow cancer of malignant plasma cells, associated with bone pain, bone fractures and anemia.

It's likely to be standing room only at the American Society of Hematology (ASH) meeting Dec. 1-4 in San Diego as data is unveiled on chimeric antigen receptor T-cell (CAR-T) therapies and other treatments targeting B-cell maturation antigen (BCMA) in advanced multiple myeloma.

Editor’s note:

Please see "ASH Preview: Darzalex And Imbruvica Changing Practice, Advances In Beta-Thalassemia And More" for additional highlights of the ASH annual meeting.

BCMA is a hot target in multiple myeloma because of its prevalence on the surface of myeloma cells – and...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

Start your 7-day free trial
Explore trusted news, analysis, and insights
Access comprehensive global coverage
Enjoy instant access – no credit card required

Start Free Trial

Already a subscriber?

J&J’s Trispecific Antibody For Myeloma Offers Improved Safety, Potency Over Bispecifics

20 Jun 2025

• By Alaric DeArment

The drugmaker presented data from its Phase I study of JNJ-79635322 at ASCO and EHA showing a 100% response rate in BCMA- and GPRC5D-naïve patients.

ASCO: Pushing The Frontiers Of ADCs

19 Jun 2025

• By Mary Jo Laffler

Antibody-drug conjugates are a major part of the oncology pipeline, and data presented at the American Society of Clinical Oncology meeting highlight the emergence of new technologies.