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AbbVie's Rova-T Disappoints As Second-Line SCLC Trial Halted

 
• By John Davis

Enrolment In the Phase III TAHOE study has been halted due to shorter overall survival in the Rova-T arm compared with the control arm.  

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The results of the TAHOE study are disappointing • Source: Shutterstock

AbbVie Inc. has reported disappointing clinical data with its investigational antibody-drug conjugate (ADC), Rova-T (rovalpituzumab tesirine), in the Phase III TAHOE study which was evaluating its use as a second-line therapy for patients with advanced small-cell lung cancer (SCLC).

The study has been halted on the recommendation of the trial's independent data monitoring committee because of a shorter overall...

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