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AZ/FibroGen's Roxadustat Superior To Epoetin-Alfa In Chronic Renal Disease With Anemia

 
• By John Davis

Positive top-line Phase III data from five studies, including the finding of superior efficacy to epotin-alfa, puts roxadustat in the driving seat as a new class of anemia agents heads toward the marketplace, but cardiovascular safety needs confirming.  

Waterfall
Top-line data on roxadustat has flowed from AstraZeneca and FibroGen • Source: Shutterstock

Just days after AstraZeneca PLC and FibroGen Inc. announced the first approval of the first-in-class anemia therapy, roxadustat, AstraZeneca has released top-line data from two Phase III clinical studies, OLYMPUS and ROCKIES, and FibroGen has released top-line data from three Phase III studies, ANDES, HIMALAYAS and SIERRAS, all showing that their primary endpoints were met.

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The big pharma’s second selection in the alliance shows novel cardiovascular therapies are high on its priority list

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