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The HOX Hypothesis: A Novel Approach To Targeted Cancer Therapy

 
• By Jo Shorthouse

Emerging Company Profile: With a Phase I clinical trial starting in Q3 and Series A funding to raise, HOX Therapeutics is taking a step out of the shadows of academia to develop its novel drug candidates in brain and prostate cancer. CEO Karl Keegan spoke to Scrip about what is next for the UK company.

Emerging Company Profile Regular column feature image Version 2

UK-based HOX Therapeutics is aiming to add therapeutic options for glioma and prostate cancer patients with its lead candidate HTL001, a small peptide drug candidate that prevents the HOX gene from binding to a group of proteins called PBX (Pre-B-cell Leukaemia Homeobox). The company and its pipeline is based on the hypothesis that inhibiting HOX-PBX binding in a highly-targeted manner could result in new therapies.

The small company employs only five people so far, and is the first commercial enterprise to target the HOX gene...

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