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Genfit Hopes To Make Case For First-Line Treatment In NASH

 
• By Joseph Haas

French company expects Phase III data later in 2019 that will demonstrate elafibranor’s ability to resolve NASH without worsening of fibrosis. Genfit also is partnered with Covance on a potential diagnostic test for NASH.

Healthy Liver

Heading into the European Association for the Study of the Liver meeting April 10-14, Genfit SA is anticipating the release of Phase III data toward year’s end that it thinks may position elafibranor as the first-line drug therapy in non-alcoholic steatohepatitis (NASH) as well as a potential backbone of combination therapy in the disease.

Genfit R&D Director Dean Hum told Scrip that his company believes elafibranor – a peroxisome proliferator accelerator receptor (PPAR) alpha/delta agonist – will offer a better cardiovascular safety profile and an ability to resolve NASH in an 18-month interim look at the Phase III RESOLVE-IT study that will differentiate it from competitor Intercept Pharmaceuticals Inc

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Stock Watch: Stock Watch: Lilly And Novo Duke Out Q1

 
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Novo Nordisk enjoyed a surprise GLP-1 agonist contracting win in the first quarter of 2025. This provided a welcome boost to its stock after it had spent the previous quarter on the back foot against rival Lilly.

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