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CymaBay Alters NASH Hypothesis After Phase IIb Failure In Hepatic Fat Reduction

 
• By Joseph Haas

Firm points to liver biomarker findings, saying they may yield clear liver benefit at 52 weeks. Both CymaBay's and Genfit's stock prices fell as investors wondered about broader read-through for the PPAR agonist class.

Many arrows missed hitting target mark. Shot miss. Multiple failed inaccurate attempts to hit archery target. Business challenge failure metaphor. Flat cartoon isolated vector object illustration
CymaBay missed a 12-week hepatic fat reduction endpoint in its Phase IIb study

CymaBay Therapeutics Inc.’s Phase IIb setback in non-alcoholic steatohepatitis (NASH) battered its stock price on 11 June and had a carryover effect for Genfit SA, which is in Phase III in NASH in the same drug class.

However, CymaBay is trying to shift the narrative on its drug seladelpar, pointing out that the PPAR delta agonist yielded notable liver biomarker improvements in the study, suggesting that

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