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Analysts Impressed As Novo Nordisk’s PIONEER 6 Trial Confirms Safety Profile Of Oral Semaglutide

 
• By Sten Stovall

Oral semaglutide hit its main endpoint by demonstrating cardiovascular safety in people with type 2 diabetes and established cardiovascular disease or high cardiovascular risk in the PIONEER 6 trial.

Heart
Trial is part of Novo Nordisk's PIONEER clinical development program • Source: Shutterstock

Novo Nordisk AS’s investigational oral version of its GLP-1 agonist semaglutide is safe in patients with type 2 diabetes at high cardiovascular risk, according to full results from the PIONEER 6 study released at the American Diabetes Association (ADA) on 11 June, which showed a non-significant 21% reduction in major adverse cardiac events (MACE).

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