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AstraZeneca's Imfinzi Sees Benefits In CASPIAN Study

 
• By John Davis

Further details of Imfinzi’s benefits in small cell lung cancer, an aggressive and poorly treated tumor, from the interim analysis of the CASPIAN Phase III study, show statistically significant and clinically meaningful activity.

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• Source: Shutterstock

AstraZeneca PLC’s checkpoint inhibitor, Imfinzi (durvalumab), combined with standard chemotherapy, has been associated with a statistically significant 27% reduction in death (with a hazard ratio of 0.73) versus chemotherapy alone when given as first-line therapy for patients with extensive-stage small cell lung cancer in the CASPIAN study.

The study also delivered a 67% response rate when patients were treated with Imfinzi plus chemotherapy, compared with a 57.6% response rate associated with chemotherapy alone, the company announced on...

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