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Boundless Bio Launches With $46m And Novel Oncology Focus On Extrachromosomal DNA

 
• By Mandy Jackson

Former Ignyta executive Zachary Hornby wasn't wowed by immuno-oncology pitches when looking for his next cancer drug development company, but was intrigued by ecDNA research at UCSD, which also could generate a tumor agnostic approach.

DNA strand and Cancer Cell Oncology Research Concept 3D rendering - Illustration
Boundless Bio is focused on extrachromosomal DNA as a cause of rapid tumor growth. • Source: Shutterstock

Former Ignyta Inc. chief operating officer Zachary Hornby helped the developer of Roche's now-approved tumor-agnostic therapy Rozlytrek (entrectinib) transition its assets to the Swiss big pharma after it was acquired for $1.7bn, then set out to find a new cancer drug development opportunity. Hornby passed on multiple immuno-oncology technologies before settling on the extrachromosomal DNA (ecDNA) work now under way at Boundless Bio, which has raised $46.4m in venture capital.

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