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POSEIDON Delivers For AstraZeneca's Imfinzi, But More Clarity Is Needed

 
• By Jessica Merrill

Imfinzi and tremelimumab plus chemotherapy improved PFS in first-line NSCLC, but overall survival is continuing to be assessed, and AstraZeneca did not clarify how the triple combination compared to Imfinzi alone with chemotherapy.

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AstraZeneca hopes to catch up to the leaders in metastatic NSCLC • Source: Shutterstock

AstraZeneca PLC’s Imfinzi (durvalumab) could be poised for expanded use in the big first-line metastatic non-small cell lung cancer market now that, at long last, a trial testing the PD-L1 inhibitor with AstraZeneca’s CTLA-4 antibody tremelimumab in first-line NSCLC met the primary endpoint of improvement in progression-free survival.

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• By Joseph Haas

Bristol Myers Squibb notched two approvals in one week for its immuno-oncology combination, pitting the regimen head-to-head with Keytruda in a subset of CRC and with two combos in HCC.

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• By Anju Ghangurde

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