Spectrum Sinks After Poziotinib Fail In NSCLC

Shares Slide 60%

The US firm has two assets but the future looks less than rosy for one of them, the lung cancer therapy poziotinib, after the drug failed a Phase II study.

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Spectrum takes a tumble after trial disappointment • Source: Shutterstock

Shares in Spectrum Pharmaceuticals Inc. have taken a battering on the news that the US firm's investigational lung cancer drug poziotinib failed to meet its main goal in a mid-stage clinical trial.

The Nevada-headquartered group reported that the primary endpoint in its Phase II trial called Zenith20 evaluating poziotinib in previously treated non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) exon 20 insertion mutations was not met in the first group of 115 patients

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