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Kronos’ Bischofberger Turns To Gilead SYK Inhibitors To Jump Start R&D

 
• By Joseph Haas

Two years after Bischofberger left Gilead for Kronos, he called upon former colleagues to acquire a SYK inhibitor program for a genetically defined subset of acute myelogenous leukemia.

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Bischofberger is jumpstarting R&D by bringing in compounds from his prior company

While Kronos Bio, Inc. is discovering and developing transcription factor-targeting cancer therapies in house, CEO Norbert Bischofberger has turned to his former home to accelerate Kronos’ business strategy by acquiring a pair of abandoned Phase II SYK inhibitors.

Privately held Kronos revealed on 16 July that it is acquiring the mid-stage compounds entospletinib and lanraplenib, which were halted in Phase II development for inflammation and hematologic malignancies, respectively, at Gilead Sciences, Inc. while Bischofberger served as chief scientific officer and head of R&D. After 28 years at Gilead, Bischofberger left in 2018, resurfacing in May as CEO at Kronos, which set a goal of developing therapies aimed at difficult-to-drug transcription factors in cancer

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