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Roche Returns To Cystic Fibrosis Fray With Enterprise Deal

Paying £75m Upfront to UK Biotech

 
• By Kevin Grogan

While Vertex appears to have the cystic fibrosis market covered with its CFTR modulators, Enterprise has been exploring another channel, TMEM16A, in the hope of developing compounds that could possibly be used by everybody with the lethal genetic disease.

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Roche inks another respiratory deal • Source: Shutterstock

Roche Holding AG is taking a multi-million pound punt to challenge Vertex Pharmaceuticals Incorporated's dominance of the cystic fibrosis market by acquiring a program from the UK's Enterprise Therapeutics Ltd which could potentially benefit all patients suffering from the devastating lung disorder, independent of genotype.

Just a couple of months after successfully dosing the first subjects in a Phase I trial for its novel inhaled cystic fibrosis therapy ETD002, Enterprise has sold the drug and other potential compounds in its TMEM16A potentiator portfolio to Roche

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