Inhibitors of DNA damage response proteins are in the spotlight after the success of PARP inhibitors, and Zentalis Pharmaceuticals's WEE1 inhibitor, ZN-c3, has been associated with promising antitumor activity in a Phase I study in heavily pre-treated, refractory cancer patients.
AACR Round-Up: Zentalis, Pieris, Hookipa And Eli Lilly
DNA Damage Response Inhibitors, Fusion Proteins And KRAS Inhibitors
Zentalis outlines promising antitumor activity associated with its WEE1 inhibitor, Phase II trials are planned for Pieris Pharmaceuticals’ fusion protein in HER2-positive cancers, while HPV-positive cancers are being targeted by Hookipa’s immunotherapeutics in arenavirus vectors, and Eli Lilly is planning early-stage clinical trials with its next-generation KRAS inhibitor.
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