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AACR Round-Up: Zentalis, Pieris, Hookipa And Eli Lilly

DNA Damage Response Inhibitors, Fusion Proteins And KRAS Inhibitors

 
• By John Davis

Zentalis outlines promising antitumor activity associated with its WEE1 inhibitor, Phase II trials are planned for Pieris Pharmaceuticals’ fusion protein in HER2-positive cancers, while HPV-positive cancers are being targeted by Hookipa’s immunotherapeutics in arenavirus vectors, and Eli Lilly is planning early-stage clinical trials with its next-generation KRAS inhibitor.  

cancer cell
The complexities of cancer cells are gradually being unpicked • Source: Shutterstock

Inhibitors of DNA damage response proteins are in the spotlight after the success of PARP inhibitors, and Zentalis Pharmaceuticals's WEE1 inhibitor, ZN-c3, has been associated with promising antitumor activity in a Phase I study in heavily pre-treated, refractory cancer patients.

WEE1 is a protein involved in DNA damage responses, and its inhibition leads to the accumulation of damaged DNA in cancer cells leading to cell death

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