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A HIV Vaccine Proves Elusive Again As J&J Study Fails

Virus Continues To Evade Vaccine Developers

 
• By Andrew McConaghie

Another vaccine failure shows that HIV’s ability to “attack, hijack and evade” the human immune system is still outwitting researchers, but J&J will continue with Phase III study of a related vaccine.

Janssen Leiden Netherlands
The HIV vaccine candidate used the same Ad26 viral vector as in J&J's COVID-19 vaccine - but found HIV a far more difficult virus to protect against.

Hopes that a vaccine to prevent HIV infection could finally be around the corner have been dashed after the failure of Johnson & Johnson's large-scale Phase IIb study in sub-Saharan Africa.

The primary analysis of the Imbokodo trial (also known as HVTN 705/HPX2008) in young women at risk of infection found...

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More from Anti-infective

GSK, Bharat On Shigella Vaccine Phase II Data Timelines, Malaria Vaccine Price Halving

 
• By Vibha Ravi

GSK tells Scrip about timelines for data expected from two Phase II trials for its Bharat Biotech-partnered shigella vaccine candidate, which puts it ahead of Limmatech/Valneva. Meanwhile, a global-first malaria vaccine, also partnered with Bharat, sees an over 50% price cut

Industry’s Vaccines Pipeline In A Changing Regulatory Landscape

 
• By Jessica Merrill

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Cidara’s Fortunes Improve Quickly With Non-Vaccine Flu-Prevention Data

 
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Shigella Vaccine Pipeline And Why It Matters

 
• By Vibha Ravi

A GSK-Bharat Biotech deal on a shigella vaccine candidate has cast a spotlight on the disease, which is the second leading cause of diarrheal deaths in children below five. Scrip looks at data from Pharmaprojects, WHO and other sources to highlight why a vaccine matters and what pharma is doing.

More from Therapy Areas

Veru’s Enobosarm Market Potential Enhanced By New Obesity Data

 
• By Aakash Babu

The late-stage biotech posted results from the maintenance extension portion of its Phase IIb QUALITY trial in which enobosarm reduced weight regain and helped preserve lean mass in patients who discontinued their semaglutide weight-loss treatment.

GSK, Bharat On Shigella Vaccine Phase II Data Timelines, Malaria Vaccine Price Halving

 
• By Vibha Ravi

GSK tells Scrip about timelines for data expected from two Phase II trials for its Bharat Biotech-partnered shigella vaccine candidate, which puts it ahead of Limmatech/Valneva. Meanwhile, a global-first malaria vaccine, also partnered with Bharat, sees an over 50% price cut

Pfizer’s Hympavzi Poised For Broader Hemophilia Label

 
• By Alaric DeArment

The drugmaker announced positive topline results for the drug in hemophilia A and B patients with inhibitors, on top of the existing approval for patients without inhibitors.