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AstraZeneca's Imfinzi/Tremelimumab Combo Conquers HIMALAYA

Improves Overall Survival In Liver Cancer Patients

 
• By Kevin Grogan

After the combination's success in the non-small cell lung cancer POSEIDON study, AstraZeneca's Imfinzi and tremelimumab could now be on the way to approval as a first-line treatment for hepatocellular carcinoma.

himalaya
Astrazeneca scales the heights in HCC trial • Source: Alamy

A combination of AstraZeneca PLC's PD-L1 inhibitor Imfinzi and its much-maligned investigational CTLA-4 inhibitor tremelimumab has sprung a very pleasant surprise by improving survival rates in liver cancer patients.

The UK major has unveiled topline results from the closely watched HIMALAYA Phase III study which showed that a single,...

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