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Lilly Furthers Precision Cancer Ambitions With Foghorn Collaboration

 
• By Joseph Haas

Building on its Loxo Oncology unit, Lilly teams with Foghorn to target cancers caused by BRG1 mutations, about 5% of all tumors, including 10% of NSCLC patients. Merck & Co. teamed up with Foghorn in 2020.

DNA
Lilly and Foghorn hope to find novel cancer approaches in DNA's compact structure

Eli Lilly and Company has been looking to add to the precision cancer therapy pipeline born out of its Loxo Oncology acquisition, and it is expanding those ambitions through a potentially wide-ranging collaboration with Foghorn Therapeutics Inc.announced on 13 December. The Flagship Pioneering-backed biotech focuses specifically on exploiting the chromatin regulatory system to discover novel therapeutic approaches to cancer, and also sees potential for the pathway in neurology and autoimmune and infectious disease.

The Cambridge, MA, biotech will get $300m cash up front from Lilly along with an $80m equity investment – 4 million shares premium priced at $20 apiece – giving the pharma a nearly 10% ownership stake in Foghorn, Foghorn CEO Adrian Gottschalk said in an interview

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