Kintor Soars On COVID Antiviral Data But Results' Significance Still Unclear

Chinese firm Kintor disclosed findings from a pivotal Phase III trial showing its androgen receptor antagonist proxalutamide achieved a 50% reduction in risk of hospitalization or death in COVID-19 patients with mild-to-moderate infection, although uncertainty remains over it being “unable to provide” a p-value in some data analyses.

China oral antiviral
proxalutamide among China's first oral antiviral candidates for COVID-19 • Source: Alamy

Hong Kong-listed Kintor Pharmaceutical Ltd. on 6 April released top-line results from a placebo-controlled, pivotal clinical trial to study its oral COVID-19 antiviral proxalutamide, marking one of the first attempts by a Chinese firm to investigate such a candidate in an international Phase III study.

A repurposed androgen receptor-targeting prostate cancer drug, proxalutamide was studied in 733 non-hospitalized patients enrolled from April to December 2021,...

More from China

US Tariff Overhang Weighs on Chinese API Exports

 

Chinese API exports to the US fell by 24% year-on-year to $255m in May, when the US and China called a truce in a previously escalating trade war.

Chinese Developers Showcase Potentially Differentiated Weight Loss Assets At ADA

 
• By 

Multiple Chinese firms presented at this year’s ADA meeting, with a focus on weight reduction efficacy for mostly early clinical stage assets. While limited information was given on lean mass preservation, several companies are progressing drugs and combos to address this need.

China Signals Restarting IPOs For Unprofitable Biotechs

 

The China Securities Regulatory Commission has proposed a new “growth tier” for the STAR Market of the Shanghai Stock Exchange, to reinstate the market’s listing standards for unprofitable firms.

Innovent Builds Metabolic Pipeline While Retaining Oncology Backbone

 
• By 

Innovent presented data on multiple pipeline assets at ASCO, including promising OS results for its first-in-class anti-PD-1/IL-2α-bias bispecific. The Chinese firm is also continuing to build out its metabolic disease portfolio and consider its partnering strategies, its CEO tells Scrip.

More from Focus On Asia

Battle For Obesity Market Shifts Gears in India: Will Wegovy Trump Mounjaro?

 

Novo Nordisk debuts Wegovy in India, gears for pole position in obesity. The Danish group’s leadership doesn’t appear too perturbed about the head start for Lilly’s Mounjaro or the imminent arrival of generic semaglutide next year.

Bitcoin Player Parataxis To Acquire Bridge Biotherapeutics After IPF Failure

 
• By 

After the failure of its lead asset in a Phase II trial earlier this year, Korea's Bridge Biotherapeutics has accepted an acquisition offer from bitcoin group Parataxis.

Chinese Developers Showcase Potentially Differentiated Weight Loss Assets At ADA

 
• By 

Multiple Chinese firms presented at this year’s ADA meeting, with a focus on weight reduction efficacy for mostly early clinical stage assets. While limited information was given on lean mass preservation, several companies are progressing drugs and combos to address this need.