1. Scrip
  2. >>Therapy Areas
  3. >>Anticancer

Roche's SERD Setback Means Menarini Retains An Edge

 
• By Jessica Merrill

Roche's giredestrant failed to show a benefit on progression-free survival in the Phase II acelERA trial in people with advanced breast cancer.

horse race
Roche's SERD failed a Phase II trial in advanced breast cancer • Source: Alamy

Roche Holding AG joined rival Sanofi with a setback in the development of an oral selective estrogen receptor degrader (SERD) for locally advanced or metastatic ER-positive/HER2-negative breast cancer, giving an edge to underdog Menarini Group, which remains the only drug maker to have a successful Phase III trial in the setting.

In disclosing the Phase II trial failure on 25 April, Roche said it was encouraged by signals suggesting that its...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Anticancer

More from Therapy Areas

Pfizer/Astellas’s Padcev Scores First Big Win In Bladder Cancer Study

 
• By Alaric DeArment

The drug, combined with Merck’s Keytruda, was successful among certain chemotherapy-ineligible MIBC patients, with another Phase III readout expected by March 2026.

Boehringer Scores First Approval For Targeted Oral Drug In HER2-Mutant NSCLC

 
• By Alaric DeArment

The US FDA approved Hernexeos for previously treated HER2-mutant NSCLC, making it the first oral option in a setting where drugs like AstraZeneca/Daiichi Sankyo’s Enhertu dominate.

Sjögren’s Success For Ianalumab Shores Up Novartis’s Pipeline-In-A-Product Plans

 
• By Alexandra Shimmings

Novartis has strengthened its argument that ianalumab, its BAFF-R inhibitor and ADCC-mediated B-cell depletor candidate, has PIP potential with successful topline results in two Phase III Sjögren’s syndrome trials, after recently dropping the product in hidradenitis suppurativa.