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Roche To Take Ionis Drug Forward Into Crowded Nephropathy Field

Also Has Potential In AMD

 
• By Andrew McConaghie

Roche is not disclosing Phase II results yet, but must exceed late-stage rival drug’s 50% reduction in protein build up to compete in immunoglobulin A nephropathy.

Ionis HQ
Roche will lead the Phase III development of the therapy, based on Ionis' antisense drug platform. • Source: Ionis

Roche is to license Ionis Pharmaceuticals’ antisense candidate IONIS-FB-LRx and take it into a Phase III study in patients with immunoglobulin A nephropathy (IgAN), an additional potential indication.

The two firms already have a collaboration for the product in eye diseases and will now add this rare and serious condition that is characterized by a build-up of immunoglobulin...

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