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Genfit Pivots To Opposite End Of The Liver Disease Spectrum

 
• By Joseph Haas

Genfit CEO Pascal Prigent talks to Scrip about the company's high-profile trial failure in NASH and the pipeline pivot to various other drug candidates for rare liver diseases.

Reinvent
Genfit has reinvented itself with a focus on rare liver diseases after missing in NASH • Source: Shutterstock

In the spring of 2020, Genfit SA very quickly went from a company hoping and planning to be the first to bring a drug therapy for non-alcoholic steatohepatitis (NASH) to market to seeing those dreams dashed as its Phase III study failed to demonstrate efficacy. The Lille, France-based firm quickly determined that there was no path forward for PPAR alpha/delta agonist elafibranor in NASH, and some observers expected the company to be sold off in pieces and dismantled.

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