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J&J/Legend’s Carvykti Data Show Earlier-Line Efficacy As Commercial Headwinds Remain

 
• By Alaric DeArment

The companies unblinded data from CARTITUDE-4, which met its primary endpoint, but analysts citing KOLs said they continue to face issues with limited manufacturing slots and out-of-spec product.

J&J/Legend announced positive results from the Phase III CARTITUDE-4 study • Source: Shutterstock

Johnson & Johnson’s Janssen Pharmaceutical Cos. and Legend Biotech Corp. have unblinded their Phase III study of the BCMA-targeted CAR-T therapy Carvykti (ciltacabtagene autoleucel) in patients with second- to fourth-line multiple myeloma after the trial met its primary endpoint. But even if the data give Carvykti a leg up over its main competitor, 2seventy Bio, Inc./Bristol Myers Squibb Company’s Abecma (idecabtagene vicleucel), ongoing production and logistical issues may make the rollout to a larger patient population particularly challenging.

Without disclosing detailed data, J&J and Legend said 27 January that the trial, CARTITUDE-4, met its primary endpoint of showing...

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BMS’s Breyanzi Stands To Further Expand Broad Lymphoma Coverage

 
• By Alaric DeArment

The drugmaker presented data at a lymphoma meeting showing strong efficacy for the CAR-T in marginal zone lymphoma, the second most common indolent lymphoma.

Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

Is Zydus’s Agenus Deal Opportunistic Or Strategic?

 
• By Vibha Ravi

Will Zydus’s acquisition and licensing deal with Agenus turn out to be a strategic move towards building an oncology portfolio or an opportunistic one driven by a venture capital mindset?

ASCO: Kite’s Glioblastoma CAR-T Highlights Solid Tumor Progress

 
• By Alaric DeArment

The company presented Phase I data for CART-EGFR-IL13Rα2, showing patient responses in the notoriously hard-to-treat and deadly brain cancer.

More from Anticancer

Early Blood Cancer Data Impresses As Incyte Plots Post-Jakafi Strategy

 
• By Kevin Grogan

First results for a first-in-class mutCALR-targeted therapy in essential thrombocythemia presented at EHA point to a lucrative future for the early-stage product.

Quick Listen: Scrip’s Five Must-Know Things

 
• By Ian Haydock

In this week's episode: breaking down big pharma’s executive pay; US vaccine panel upheaval; Merck’s RSV approval; MFN and Japan; and the future of Pfizer and Arvinas’s partnership.

UroGen Gets A First-Ever Bladder Cancer Approval Despite US FDA AdComm ‘No’ Vote

 
• By Joseph Haas

UroGen’s Zusduri was approved despite an advisory committee vote recommending against it in May. It is the first approved drug for a type of recurring bladder cancer.