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ICER: Madrigal’s Resmetirom Looks More Cost-Effective In NASH Than Intercept’s OCA

 
• By Joseph Haas

In a draft assessment, the non-profit said Madrigal’s non-alcoholic steatohepatitis candidate might yield cost savings over a lifetime of care. Both drugs seem to offer incremental benefits for survival and quality of life.

Economic review
ICER's draft review of leading NASH candidates finds some cost benefit for one • Source: Shutterstock

The Institute for Clinical and Economic Review (ICER) issued a draft assessment on 16 February finding that Madrigal Pharmaceuticals, Inc.’s Phase III non-alcoholic steatohepatitis (NASH) candidate resmetirom (MGL-3196) appears to offer cost-saving potential to the US health care system, while Intercept Pharmaceuticals, Inc.’s obeticholic acid (OCA) would not meet cost-effectiveness thresholds unless the drug’s pricing was reduced from the formulation approved as Ocaliva to treat primary biliary cholangitis (PBC).

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