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Janssen Gives Next-Gen CAR-Ts Another Shot After Fate Deal’s Collapse

J&J Inks New $245m Partnership With Cellular Biomedicine

 
• By Alaric DeArment

A new collaboration with Cellular Biomedicine includes a CD19/CD20-directed bispecific CAR-T in Phase I development for B-cell non-Hodgkin lymphomas.

Janssen announced a cell therapy-focused partnership with CBMG • Source: Shutterstock

Months after another next-generation cell therapy deal fell apart, Johnson & Johnson Janssen Biotech, Inc. is back in the ring with another one, this time with Cellular Biomedicine Group, Inc. (CBMG), in a partnership focused on developing CD20-directed autologous CAR-T cells, including a bispecific candidate against CD19 and CD20.

Janssen said 2 May that it had entered a global partnership and licensing deal with CBMG to develop, manufacture and commercialize CAR-Ts for B-cell malignancies, including the CD20-directed C-CAR066 and the CD19/CD20-directed bispecific CAR-T C-CAR039. Both are in development for B-cell lymphomas, primarily diffuse large B-cell lymphoma (DLBCL)

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