Can BlissBio’s HER2-Targeting ADC Challenge Enhertu In Breast Cancer?

Eisai Deal Sets Stage For Battle

A new deal worth up to $2bn-plus with Eisai has put Bliss Biopharmaceutical's HER2-targeting antibody-drug conjugate BB-1701 in the spotlight, as the global race heats up to find a possible challenger to Enhertu.

challenger facing hurdles
Any serious challenger to Enhertu will face hurdles, especially in breast cancer • Source: Shutterstock

Japanese major Eisai Co., Ltd.’s option deal worth up to $2bn-plus for the in-licensing of a HER2-targeting antibody-drug conjugate (ADC) developed by Chinese biotech Bliss Biopharmaceutical (BlissBio), showed just how intensively international pharma firms are scouting China-originated assets for a potential challenger to Daiichi Sankyo Co., Ltd./AstraZeneca PLC's Enhertu (trastuzumab deruxtecan) for breast cancer.

Eisai and BlissBio announced on 8 May a clinical trial collaboration agreement with an option for a strategic collaboration for BB-1701 outside greater China. Should Eisai exercise its option, its Chinese partner will receive an exercise payment and be eligible for development and commercial milestone payments of up to an aggregated $2bn, as well as royalties on sales

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