ESMO 23: Opdivo Matches Keytruda In Perioperative Lung Cancer

Bristol Myers Squibb’s PD-1 looks set to follow Merck & Co’s rival in a new lung cancer setting but might second place be the first loser?    

Group of surgeons doing surgery in hospital operating theater. Medical team doing critical operation. -

A success – and a pretty good one. New data on Opdivo revealed in a late-breaking abstract released early at this weekend’s European Society for Medical Oncology (ESMO) meeting in Madrid, suggests that Bristol Myers Squibb Company’s checkpoint inhibitor might be a serious rival to Merck & Co., Inc.’s powerhouse Keytruda.

Key Takeaways
  • Opdivo cuts the risk of progression, recurrence or death by 42% when used perioperatively for non-small cell lung cancer
  • This is the exact same benefit Keytruda showed in its comparable trial
  • But Keytruda reached market first and Bristol will

The setting is perioperative non-small cell lung cancer (NSCLC), in which a drug, plus chemotherapy, is given both before and after tumor resection. Keytruda (pembrolizumab) was approved for this use just this week, and now it looks highly probable that Opdivo (nivolumab) will join it

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