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ESMO 23: Kelun/Merck, Hansoh ADCs Impress With Early Data In Breast Cancer

 
• By Dexter Jie Yan

In new data from Chinese developers at ESMO, Kelun/Merck’s Trop2-targeting ADC SKB264 (MK-2870) appears ready to hog the limelight from Daiichi Sankyo/AstraZeneca’s Dato-DXd, while Hansoh’s B7-H4-targeting HS-20089 is coming to the fore against its global same-class competitors. There were also new clinical results for Mabwell/Hengrui’s Nectin-4-targeting 9MW2821 and HER2-targeting SHR-A1811.

stage limelight
ESMO Congress turns spotlight on ADCs from Chinese developers • Source: Shutterstock

Chinese-made antibody-drug conjugates (ADCs) are poised to come from behind as fast-followers of their global peers on the back of impressive new Phase I and II clinical data to be orally reported at the European Society for Medical Oncology (ESMO) Congress, being held in Madrid, Spain over 20-24 October.

Key Takeaways

  • Kelun/Merck, Hansoh's ADCs, targeting Trop2 and B7-H4 respectively, shine at ESMO with impressive early-stage clinical outcomes versus global front-runners.

Breast cancer has emerged as one of the main areas of focus. 

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More from China

China Signals Restarting IPOs For Unprofitable Biotechs

 
• By Dexter Jie Yan

The China Securities Regulatory Commission has proposed a new “growth tier” for the STAR Market of the Shanghai Stock Exchange, to reinstate the market’s listing standards for unprofitable firms.

Innovent Builds Metabolic Pipeline While Retaining Oncology Backbone

 
• By Xu Hu

Innovent presented data on multiple pipeline assets at ASCO, including promising OS results for its first-in-class anti-PD-1/IL-2α-bias bispecific. The Chinese firm is also continuing to build out its metabolic disease portfolio and consider its partnering strategies, its CEO tells Scrip.

Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

AstraZeneca Taps Into China’s R&D Engine With CSPC Alliance

 
• By Andrew McConaghie

After in-licensing a cardiovascular candidate last year, AstraZeneca has signed a strategic drug discovery alliance, which could generate billions of dollars in payments to the Chinese firm.

More from Focus On Asia

Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

Big Top-Level Shifts At Sun: Ganorkar Is MD, Ex-Takeda Exec To Helm US Business

 
• By Anju Ghangurde

Sun’s founder hands top job to company longtimer Kirti Ganorkar as the firm implements a “structured and forward-looking” succession plan, while Richard Ascroft will lead the Indian drugmaker’s North America business.

AstraZeneca Taps Into China’s R&D Engine With CSPC Alliance

 
• By Andrew McConaghie

After in-licensing a cardiovascular candidate last year, AstraZeneca has signed a strategic drug discovery alliance, which could generate billions of dollars in payments to the Chinese firm.