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ESMO 23: Concerns Despite Unprecedented Early-Stage Lung Cancer Win For Roche’s Alecensa

 
• By Kevin Grogan

The Swiss group's ALK inhibitor Alecensa improved disease-free survival by 76% in early-stage patients with the mutation, a first for the class, but an ESMO discussant raises questions about toxicity and treatment burden.

ESMO 2023 exterior
• Source: ESMO

Comfortably the market leader in treating advanced anaplastic lymphoma kinase (ALK)-positive lung cancer, the extent of the Phase III success of Roche Holding AG's Alecensa in tackling the early stage of the disease has caused a stir at the European Society for Medical Oncology congress in Madrid.

The Swiss major signalled in September that in the 257-patient Phase III ALINA study, Alecensa (alectinib) achieved an "unprecedented" improvement...

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• By Manas Mishra

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AstraZeneca’s Tagrisso Mountain Grows, But The Climb Will Be Challenging

 
• By Aakash Babu

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Quick Listen: Scrip’s Five Must-Know Things

 
• By Ian Haydock

In this week's episode: EU tariff deal leaves questions for pharma; Prasad’s CBER exit could bode well for genetic medicines; Winrevair grows but Merck & Co. plans cost cuts; Novo Nordisk selects new CEO; and a look at obesity past the GLP-1s.