ESMO 23: Amgen's Lumakras/Vectibix Combo Clinches Colorectal Cancer Win

The higher dose of Amgen's Lumakras combined with Vectibix has demonstrated significant superiority in progression-free survival over investigator's choice of therapy in KRAS G12C-mutated metastatic colorectal cancer but the discussant at the combo's ESMO presentation wants to see overall survival data before getting too excited.

ESMO Lumakras CRC
Filippo Pietrantonio presents CodeBreak 300 at the Madrid meeting • Source: ESMO

Amgen, Inc. caused a stir at the European Society for Medical Oncology meeting in Madrid with promising data for its small-cell lung cancer offering tarlatamab but the reception for a late-stage study looking at a combination of its KRAS G12C inhibitor Lumakras and Vectibix for colorectal cancer was a bit cooler.

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