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Emerging Company Profile: Chinese siRNA Specialist Sirius All In On Cardiovascular Disease

Potential Once-Yearly Regimen

 
• By Dexter Jie Yan

Sirius has joined the race to develop China’s first homegrown RNAi therapy and is backing its assets’ potential in chronic cardiovascular disorders, including possible once-yearly dosing, the venture’s CEO tells Scrip in an interview.

cardiovascular diseases
Chinese siRNA therapy developer aims at cardiovascular diseases with potential once-yearly regimen • Source: Shutterstock

The first days of the new year witnessed multinationals including Novartis AG tie up with developers of small interfering RNA therapies from China, once regarded as a backwater for R&D into such a novel drug modality. (Also see "Asia Deal Watch: Argo Partners RNAi Programs With Novartis In Major Biobucks Pact" - Scrip, 8 January, 2024.) (Also see "BI Gets Down To Business Early With Trio Of Pacts" - Scrip, 5 January, 2024.)

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Arbele Leverages Rights As It Drugs Proprietary CDH17 Target

 
• By Dexter Jie Yan

Arbele has emerged as a global leader in the Cadherin 17 area, not only in clinical progress but also for its “secret recipe” for application in T-cell engagers, its CEO tells Scrip.

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More from Focus On Asia

Asia Deal Watch: Daiichi Taps Into Wayfinder’s RNA-Encoding Platform

 
• By Jung Won Shin, Lisa Takagi, Joseph Haas, Anju Ghangurde, and Vibha Ravi

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Japanese incubator Ciconia has just started verifying its first drug candidate with a vision of building domestic startups with globally competitive assets.

Henlius In David Versus Goliath Race With Pfizer For First PD-L1 ADC

 
• By Dexter Jie Yan

While Henlius Biotech’s PD-L1-targeting antibody-drug conjugate HLX43 is struggling to catch up with Pfizer’s PF-08046054, the global frontrunner in the space, a key differentiation of the China-originated asset could lie in PD-L1-negative patients.