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Avistone Wins China Approval For First C-Met Inhibitor In Glioblastoma

 
• By Dexter Jie Yan

A China green light for domestic firm Avistone's c-Met inhibitor was based on positive outcomes from the Phase II/III FUGEN study in Chinese patients with recurrent relapsing glioma with the rare PTPRZ1-MET fusion gene. Avistone’s overseas partner Apollomics is also studying the molecule in a Phase II program outside China.

glioblastoma
Avistone's vebreltinib found effective for rare subtype of glioblastoma in China Phase II/III trial • Source: Shutterstock

Chinese biotech Avistone Pharmaceuticals has won full approval in China for vebreltinib (also known as bozitinib) for a rare subtype of glioblastoma, making the molecule the world’s first c-Met inhibitor to be green-lighted for this form of central nervous system tumor with c-Met alterations.

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