Ensho Therapeutics Inc. launched on 27 June to announce that it will start Phase II clinical trials in ulcerative colitis (UC) during the first half of 2025 for lead drug candidate NSHO-101 (EA1080), an oral alpha-4 beta-7 (ɑ4β7) integrin inhibitor licensed from Eisai Co., Ltd.’s gastrointestinal disease subsidiary EA Pharma Co., Ltd.
Ensho Joins Race To Develop An Oral Integrin Inhibitor For IBD
Start-Up Licensed Lead Drug From Eisai Subsidiary
Ensho Therapeutics is raising series A cash to develop Phase II-ready NSHO-101 (EA1080), a third oral ɑ4β7 integrin inhibitor attempting to take on Takeda’s blockbuster injectable Entyvio.

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