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Genmab Relies On Pipeline As J&J Opts Out Of Next-Gen Darzalex

Epkinly, Rina-S, Acasunlimab To Deliver Revenue Growth

 
• By Mandy Jackson

J&J’s decision about whether to in-license HexaBody-CD38 (GEN3014) was seen as a key milestone for Genmab this year, but without the opt-in the company is discontinuing development.

With or without a GEN3014 deal, Genmab is seeking growth through late-stage dealmaking (Shutterstock)

The pressure on Genmab to deliver positive results from its late-stage development programs has intensified now that the most closely watched event on the company’s 2025 calendar has arrived and the result was not as investors hoped. Genmab said on 10 March that Johnson & Johnson opted not to in-license HexaBody-CD38 (GEN3014), a next-generation version of the companies’ blockbuster CD38 inhibitor Darzalex (daratumumab).

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Pipeline Watch: Eight Approvals And Three Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.