Verve Can Shrug Off Vertex Loss But Lilly Opt-In Is Crucial

The company will soon have Phase I data on its in vivo gene-editing PSCK9 inhibitor and hopes Lilly is persuaded to opt into its development.

Verve Therapeutics

Verve Therapeutics’ loss of Vertex as a partner has generated headlines this week but the gene-editing company’s real make-or-break moment could be just around the corner.

The in vivo base editing biotech announced on 28 February that Vertex was withdrawing from a collaboration established in 2022, which had brought in $25m upfront in cash and had held the promise of up to $406m in development and commercial milestones

Key Takeaways
  • Verve has lost two-thirds of its market cap since April 2024, reflecting safety concerns about its former candidate, plus a wider downturn in the once-hyped gene-editing field

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