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Merck & Co. Calls Time On Flop TIGIT And LAG-3 Programs

 
• By Andrew McConaghie

After investing heavily in both mechanisms for IO-IO combinations, Merck is cutting its losses with vibostolimab and favezelimab, and switching its anticancer bets to other modalities.

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Once a key part of its next-generation plans in cancer, Merck & Co. has called a halt to the last remaining Phase III studies of its TIGIT- and LAG-3 targeting immunotherapy assets.

The two immunotherapy mechanisms had been seen as strong contenders for use in combination with anti-PD-1/L-1 checkpoint inhibitors, most notably...

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