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BioAge’s Hopes For Combo Obesity Drug Dim Due To Liver Safety

Phase II Trial, Designed With Lilly, Cancelled

 
• By Jessica Merrill

The company discontinued the Phase II STRIDES study testing azelaprag as monotherapy and in combination with Lilly’s tirzepatide in obesity.

(Shutterstock)

In a big setback for BioAge Labs, the company is discontinuing a Phase II trial of its lead drug azelaprag for obesity after cases of liver transaminitis were observed in some patients taking the drug – but it isn’t discontinuing the development program until it reviews all the data.

The company announced the news on 8 December, just over two months after the company completed an initial public offering in September at a price of $18 per share....

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