Glucagon-like peptide-1 (GLP-1) receptor agonists, particularly Novo Nordisk’s Wegovy (semaglutide) and Eli Lilly’s Zepbound (tirzepatide), have made a significant difference for patients with obesity, on top of netting blockbuster sales for the two manufacturers. But the enormous market size is proving to be unsustainable for payers, leading the Institute for Clinical and Economic Review (ICER) to suggest additional ways to handle the costs of the drugs.
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