Gilead Pushes PrEP Envelope As ViiV Explores Self-Administered, Long-Acting Drugs

The two companies were among those presenting data at CROI that highlighted the next frontiers of competition in the HIV space.

HIV prep
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Gilead Sciences’ lenacapavir is already expected to have a significant advantage among injected HIV drugs thanks to its twice-yearly injection schedule when the company launches it for pre-exposure prophylaxis (PrEP), but now it has Phase I data showing PrEP efficacy as a single annual injection. Gilead presented the data on 11 March at the Conference on Retroviruses and Opportunistic Infections (CROI).

Key Takeaways
  • As it awaits the launch of twice-yearly lenacapavir for PrEP, Gilead stirred the competitive pot further with early data indicating the potential for once-yearly administration.

The Foster City, CA-based drug maker further presented on 12 March Phase II data showing the efficacy of lenacapavir combined with the broadly neutralizing antibodies (bNAbs) teropavimab and zinlirvimab as...

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