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Gilead Set To Expand Trodelvy/Keytruda Into Frontline TNBC

 
• By Alaric DeArment

The company reported positive topline results for ASCENT-04, which also bode well for the ASCENT-03 trial in patients with low PD-L1 expression.

• Source: Shutterstock

Gilead Sciences is looking to expand the reach of Trodelvy (sacituzumab govitecan-hziy) into the frontline setting of triple-negative breast cancer (TNBC) based on positive topline results in combination with Merck & Co.’s Keytruda (pembrolizumab). The results are also an encouraging sign for the larger indication of TNBC patients with low PD-L1 expression who are not candidates for checkpoint inhibitors.

Key Takeaways
  • Gilead announced positive topline results from its trial of Trodelvy combined with Keytruda in first-line, PD-L1-positive, inoperable, locally advanced or metastatic triple-negative breast cancer.

Without disclosing numerical data, the Foster City, CA-based drug maker announced 21 April that the Phase III ASCENT-04/KEYNOTE-D19 study showed superior progression-free survival (PFS) for Trodelvy/Keytruda compared with Keytruda combined...

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