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Dynamis Therapeutics Inc.

Pharmaceuticals for diabetic nephropathy

Advanced Glycation End products (AGEs), protein/glucose complexes that cross-link proteins and accumulate over time in various tissues, have been blamed for the ravages of aging as well as more specific diseases, including diabetic nephropathy. Scientists at the Fox Chase Cancer Center have discovered an enzyme pathway which leads to the formation of a precursor of AGEs. With consulting firm QED Technologies LP, which provides funding and management, the center has formed Dynamis Therapeutics Inc. , a 50-50 joint venture bent on discovering therapeutics which ultimately prevent the formation of AGEs and the diseases that they cause.

The new company's patents (pending) cover small molecules that inhibit the enzyme Amadorase, and so, says the company, prevent the...

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