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Start-Up Previews

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Start-Ups Against Inflammation," features profiles of Asphleia Pharmaceuticals, Calistoga Pharmaceuticals, ProtAb Ltd., and Resolvyx Pharmaceuticals. Plus these Start-Ups Across Health Care: CG Therapeutics, Healionics, Mpathy Medical Devices and Pronostics.

In an era of high-tech medicine, of painstakingly designed molecular inhibitors and personalized medicine driven by genetic responses to drugs, [Asphelia Pharmaceuticals Inc.] Also see "Asphelia Pharmaceuticals Inc." - Scrip, 1 June, 2008. is placing its bets on a primitive technology: intestinal worms, known as helminthes. Helminthes release proteins that boost the activity of regulatory T-cells, and the antigens they produce appear to influence a variety of targets. Asphelia is developing helminthes as an oral treatment for Crohn’s and other autoimmune diseases. Also in the company’s pipeline, a novel oral compound that targets integrins in order to treat immunological and inflammatory disorders.

Formed around a preclinical program licensed from Icos, Calistoga Pharmaceuticals Inc. [A#2008900126] is developing multiple small-molecule inhibitors of the phosphoinositide-3...

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