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Can E6E7 Alter The Competitive Balance In The Crowded HPV Test Market?

The October introduction of Gen-Probe’s new cervical cancer screening test may up the stakes in the battle over market share in testing for HPV, the cause of cervical cancer. That’s good news for several companies. One is OncoHealth, which is developing a low-cost protein-based test for direct measurement of E6E7, two important oncoproteins associated with HPV progression to cancer that are a part of Gen-Probe’s new test panel.

FDA approval of Gen-Probe Inc.’s Aptima cervical cancer screening test in late October may well mark a step-up in the continuing battle for share in the $300 million market for nucleic-acid-based tests for the presence of human papilloma virus (HPV), the cause of virtually all cervical cancer. More broadly, the introduction of new HPV markers could shift the dynamics of the $2-billion-plus overall market for cervical screening and diagnosis, potentially diminishing at long last the use of the Pap smear as a primary screening tool.

The hope of turning away from cytology and toward more direct HPV testing is not new. A decade ago, it...

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