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The Tumor-Agnostic Developer’s Toolkit

Eight Criteria To Consider For Next-Generation Agnostic Drugs

 
• By Daniel Chancellor

In Vivo has identified the pipeline of next-generation tumor-agnostic drugs and created a guide to the ideal trial strategies for these potentially transformative candidates.

Tools

Last year saw a continuation of the emerging trend within oncology of developing drugs that are tumor agnostic, designed to be used in patients whose tumor is characterized not by its location, but rather by a molecular or genetic signature. Most recently, the FDA approved Roche’s TRK inhibitor Rozlytrek (entrectinib) for patients with NTRK gene fusion-positive solid tumors, prompting then-FDA commissioner Ned Sharpless to effuse about the therapeutic potential of this personalized, precision oncology approach.“We are in an exciting era of innovation in cancer treatment as we continue to see development in tissue agnostic therapies, which have the potential to transform cancer treatment,” Sharpless said in August 2019.

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